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Poly(ADP-ribose) polymerase inhibition: past, present and future

Crit Rev Oncology/Hematology

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321 APR-246 suppresses the growth of tumors expressing mutant p53 through various pathways, such as degrading cellular glutathione levels, promoting endoplasmic reticulum (ER) responses, and adjusting oxidationreduction responses to induce ferroptosis